Solute Carrier Organic Anion Transporter Family, Member 1A3 (SLCO1A3)
Oatp1a3; Slc21a4; OAT-K; Solute Carrier Family 21 Member 1; Sodium-Independent Organic Anion Transporter K1
SLCO1A3, Belongs to the organo anion transporter (TC 2.A.60) family.Contains 1 Kazal-like domain. Tissue specificity All isoforms are detected in kidney, and many are kidney specific. Isoforms 2 and 13 are also detected in liver. Isoforms 4 and 9/K4 are ubiquitous, but isoform 9/K13 is kidney specific. Isoforms 5 and 14 are detected in all tissues tested, with the exception of pancreas and spleen. Isoforms 11 and 15 are detected in kidney, pancreas and testis. Isoform 7 is detected in kidney, liver, testis and spleen.
Mediates the Na+-independent transport of organic anions such as methotrexate, taurocholate, folate and prostaglandin E2. May contribute to renal secretion and/or reabsorption of hydrophobic anionic compounds. Mediates renal clearance of methotrexate from the blood.
Organism species: Rattus norvegicus (Rat)
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