Somatostatin Receptor 4 (SSTR4)

SSTR4, which is specifically expressed in human fetal and adult brain and lung tissue. SSTR4 shared structural features with the superfamily of receptors having 7 transmembrane segments. It had a 1,167-bp open reading frame encoding a protein of 388 amino acids with a predicted molecular size of 42 kD. Its amino acid sequence showed 58, 43, and 41% identity with the sequences of SSTR1, SSTR2, and SSTR3 , respectively.

Fluorescence in situ hybridization using a probe for SSTR4 in combination with probes for neuroendocrine convertase-2 (NEC2), thrombomodulin (THBD), and brain glycogen phosphorylase (PYGB) established the following order: 20pter--NEC2--SSTR4--THBD--PYGB--cen.