Somatostatin Receptor 1 (SSTR1)

An SSTR1 probe hybridized to multiple DNA fragments in EcoRI digests of human and mouse DNA, indicating that SSTR1 and SSTR2 are members of a larger family of somatostatin receptors. Thus, the biologic effects of somatostatin are probably mediated by a family of receptors that are expressed in a tissue-specific manner. Bruno et al. (1992) cloned a brain-specific somatostatin receptor in the rat. Its deduced amino acid sequence showed a 60% and 48% identity to SSTR1 and SSTR2, respectively. By analysis of segregation in a panel of reduced human-hamster somatic cell hybrids, Yamada et al. (1993) assigned the SSTR1 gene to chromosome 14. They confirmed the assignment by fluorescence in situ hybridization and regionalized the locus to 14q13.