Sortilin Related VPS10 Domain Containing Receptor 2 (SORCS2)

SORCS2 encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. SORCS1 and SORCS3 share the greatest homology. SORCS2 shares the same domain composition, but is less similar. SORT1 and SORTL1 lack the leucine-rich domain of the SORCS proteins, and their VPS10 domains are less related.