Sorting Nexin 12 (SNX12)

Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain or through protein-protein interactions with membrane-associated protein complexes Some members of this family have been shown to facilitate protein sorting. Sorting nexins either consist solely of a PX domain or have a modular structure made up of the PX and additional domains.

SNX12 encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function.