Sorting Nexin 26 (SNX26)

SNX26 is a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The specific function of this protein has not been elucidated. Alternative splice variants have been described but their full length nature has not been determined. Sorting nexins are a large group of proteins with the common characteristic of having a PX domain. Some members of this family have been shown to facilitate protein sorting. Sorting nexins either consist solely of a PX domain (SNX3) or have a modular structure made up of the PX and additional domains. The presence of RhoGAP domains in a number of different human proteins suggests that cytoskeletal changes, regulated by Rho GTPase, may be integrated with many different signaling pathways.