Spermatogenesis Associated Protein 7 (SPATA7)
HSD3; Spermatogenesis-associated protein HSD3
SPATA7 encodes a 599-amino acid protein containing several DNA-binding sites and 3 phosphorylation sites. The human and rat SPATA7 proteins share 77% sequence identity. Northern blot analysis of rat tissues showed testis-specific expression, which was first detected at postnatal day 30. Immunohistochemistry of rat testis localized SPATA7 to primary spermatocytes in early prophase of meiosis I.
Mutation analysis in additional patients revealed homozygosity for the same R108X mutation in a Dutch LCA patient as well as a frameshift mutation in another LCA patient of Middle Eastern origin; homozygosity for different nonsense and frameshift mutations in SPATA7 was also identified in 2 patients with juvenile retinitis pigmentosa.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Spermatogenesis Associated Protein 7 (SPATA7) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Spermatogenesis Associated Protein 7 (SPATA7) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Spermatogenesis Associated Protein 7 (SPATA7) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Spermatogenesis Associated Protein 7 (SPATA7) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Spermatogenesis Associated Protein 7 (SPATA7) ELISA Kit Customized Service Offer