Spermidine/Spermine N1-Acetyltransferase 2 (SAT2)

In the polyamine back-conversion pathway, spermidine/spermine N(1)-acetyltransferase-1 (SAT1) acetylates spermine and spermidine, which are then oxidized by polyamine oxidase to produce spermidine and putrescine, respectively.

The deduced 170-amino acid protein has a calculated molecular mass of 19 kD and has 46% amino acid identity to SAT1.SAT2 homologs were found in a variety of species from bacteria to eukaryotes in all major lineages. All species below vertebrates had 1 copy of SSAT, whereas all vertebrate species, with the exception of chicken and Xenopus, had functional SAT1 and SAT2 genes. SAT1 was expressed at higher levels than SAT2 and in a wider range of tissues, although bone, cervix, ovary, and pineal gland expressed only SAT2.