Spindle Assembly 6 Homolog (SASS6)

SAS6 is necessary for centrosome duplication and functions during procentriole formation; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle.

SAS6 associated only transiently with nascent procentrioles, whereas CEP135 and CPAP formed a core structure within the proximal lumen of both parental and nascent centrioles. SAS6 was necessary for procentriole formation in human cell lines, and that SAS6 localized asymmetrically next to the centriole at the onset of procentriole formation, prior to the recruitment of CETN2. SAS6 levels oscillated during the cell cycle; it was degraded in mitosis starting at anaphase, and it accumulated again at the end of the following G1 phase.