Spindlin 2B (SPIN2B)

SPIN-2; Spindlin-like protein 2B

Spindlin 2B (SPIN2B)
The deduced 258-amino acid protein has a C-terminal potential ribonucleotide-binding site and a tyrosine phosphorylation site. SPIN2 and DXF34 are nearly identical at the nucleotide level and differ primarily in their extreme 5-prime UTRs. The SPIN2 and DXF34 proteins are identical except for 1 amino acid difference.
The SPIN2 protein also shows high similarity to human spindlin (SPIN) and mouse Ssty. RNA dot blot analysis detected SPIN2 in all tissues examined, with highest expression in adult and fetal liver, followed by heart, stomach, kidney, skeletal muscle, placenta, and pancreas. Epitope-tagged SPIN2 localized in the nucleus of a transduced mouse fibroblast cell line. Western blot analysis detected SPIN2 at an apparent molecular mass of 32 kD.

Organism species: Homo sapiens (Human)