SplA/Ryanodine Receptor Domain And SOCS Box Containing Protein 2 (SPSB2)

SPSB2 encodes a suppressor of cytokine signaling (SOCS) family member, and it belongs to the subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal SOCS box. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants.

By database analysis, followed by PCR of a human kidney cDNA library, Wang et al. (2005) cloned SPSB2, which they called SSB2. The deduced 263-amino acid protein shares 50% amino acid identity with SPSB1 . SPSB2 contains a central SPRY domain and a C-terminal SOCS box. Coimmunoprecipitation studies showed that SPSB2 interacted with MET.