Serine/Arginine Rich Splicing Factor 8 (SRSF8)

SFRS8 encodes a human homolog of Drosophila splicing regulatory protein. This gene autoregulates its expression by control of splicing of its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Multiple alternatively spliced variants have been identified although their full-length natures have not been characterized to date.

The human gene encodes a 951-amino acid polypeptide containing putative nuclear localization sequences, an arginine- and serine-rich (R/S) domain, and 2 repeated modules, known as surp modules, which are homologous to regions in the constitutive splicing factor SPP91/PRP21. SWAP expression is regulated, presumably autogeneously, by control of splicing of the first 2 introns.