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ITEM PROTEIN ANTIBODY ASSAY KIT CELL
Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)
SPRED1 is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). 
Overexpression of Spred1 inhibited NGF-induced neurite differentiation in rat PC12 cells, and both the EVH1 and SPRY domains were essential for the suppression.mouse Spred1 coprecipitated with and was phosphorylated by a constitutively activated Kit mutant. The KBD was required for Kit binding, but suppression of growth factor-induced MAP kinase required the SPRY domain.
Organism species: Homo sapiens (Human)
CATALOG NO. PRODUCT NAME
Proteins RPL017Hu01 Recombinant Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1) Customize
Antibodies PAL017Hu01 Polyclonal Antibody to Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1) Customize
MAL017Hu21 Monoclonal Antibody to Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1) Customize
Assay Kits SEL017Hu ELISA Kit for Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1) Customize
SCL017Hu CLIA Kit for Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1) Customize
Organism species: Mus musculus (Mouse)
CATALOG NO. PRODUCT NAME
Proteins RPL017Mu01 Recombinant Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1) Customize
Antibodies PAL017Mu01 Polyclonal Antibody to Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1) Customize
MAL017Mu21 Monoclonal Antibody to Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1) Customize
Assay Kits SEL017Mu ELISA Kit for Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1) Customize
SCL017Mu CLIA Kit for Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1) Customize
Organism species: Rattus norvegicus (Rat)
CATALOG NO. PRODUCT NAME
Proteins RPL017Ra01 Recombinant Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1) Customize
Antibodies PAL017Ra01 Polyclonal Antibody to Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1) Customize
MAL017Ra21 Monoclonal Antibody to Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1) Customize
Assay Kits SEL017Ra ELISA Kit for Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1) Customize
SCL017Ra CLIA Kit for Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1) Customize