Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)

Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)
SPRED1 is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).
Overexpression of Spred1 inhibited NGF-induced neurite differentiation in rat PC12 cells, and both the EVH1 and SPRY domains were essential for the suppression.mouse Spred1 coprecipitated with and was phosphorylated by a constitutively activated Kit mutant. The KBD was required for Kit binding, but suppression of growth factor-induced MAP kinase required the SPRY domain.

Organism species: Homo sapiens (Human)

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Organism species: Mus musculus (Mouse)

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  • Customized Servicen/aCLIA Kit for Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)

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  • Customized Servicen/aPolyclonal Antibody to Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Polyclonal Antibody Customized Service Offer
  • Customized Servicen/aCLIA Kit for Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)CLIA Kit Customized Service Offer
  • Customized Servicen/aELISA Kit for Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)ELISA Kit Customized Service Offer