Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)

Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)
SPRED1 is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). 
Overexpression of Spred1 inhibited NGF-induced neurite differentiation in rat PC12 cells, and both the EVH1 and SPRY domains were essential for the suppression.mouse Spred1 coprecipitated with and was phosphorylated by a constitutively activated Kit mutant. The KBD was required for Kit binding, but suppression of growth factor-induced MAP kinase required the SPRY domain.
Organism species: Homo sapiens (Human)
  • Protein RPL017Hu01Recombinant Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Customize
  • AntibodyPAL017Hu01Polyclonal Antibody to Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Customize
  • AntibodyMAL017Hu21Monoclonal Antibody to Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Customize
  • Assay KitSEL017HuELISA Kit for Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Customize
  • Assay KitSCL017HuCLIA Kit for Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPL017Mu01Recombinant Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Customize
  • AntibodyPAL017Mu01Polyclonal Antibody to Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Customize
  • AntibodyMAL017Mu21Monoclonal Antibody to Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Customize
  • Assay KitSEL017MuELISA Kit for Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Customize
  • Assay KitSCL017MuCLIA Kit for Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPL017Ra01Recombinant Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Customize
  • AntibodyPAL017Ra01Polyclonal Antibody to Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Customize
  • AntibodyMAL017Ra21Monoclonal Antibody to Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Customize
  • Assay KitSEL017RaELISA Kit for Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Customize
  • Assay KitSCL017RaCLIA Kit for Sprouty Related, EVH1 Domain Containing Protein 1 (SPRED1)Customize
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