Src Kinase Associated Phosphoprotein 2 (SKAP2)

SKAP2 belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation.Sequence analysis predicted that the 359-amino acid SKAP55R protein shares 44% amino acid identity with SKAP55. Like SKAP55, SKAP55R contains a pleckstrin homology (PH) domain, multiple tyrosine phosphorylation sites, and an SH3 domain; however, unlike SKAP55, SKAP55R has an N-terminal coiled-coil domain. Immunoblot analysis showed that FYB binds SKAP55 and SKAP55R equally through their SH3 domains in T cells. The authors found that like SKAP55, SKAP55R is phosphorylated by FYN.