Stathmin 3 (STMN3)

STMN3 belongs to the stathmin/oncoprotein 18 family of microtubule-destabilizing phosphoproteins. The deduced 180-amino acid protein has a calculated molecular mass of 21 kD and shares 70% amino acid identity with SCG10 (STMN2). Sclip contains an N-terminal 9-amino acid signature sequence and a putative alpha-helical domain predicted to form coiled-coil interactions with other proteins. It has 2 cysteines that may be palmitoylated and 4 consensus phosphorylation sites.Human STMN3 shares 95% amino acid identity with the mouse protein and has the same structural features, including the 2 cysteines and predicted phosphorylation sites. Northern blot analysis of rat tissues detected a major 1.2-kb transcript highly expressed in neonatal and adult brain; expression was not detected in other tissues examined.