Sterile Alpha Motif Domain Containing 9 Like Protein (SaMD9L)

SAMD9L gene contains 6 exons spanning 17.6 kb. It has a TATA signal and 2 predicted LEF (LEF1)-binding elements.During their analysis of the SAMD9 gene, Li et al. (2007) identified SAMD9L, and they amplified full-length SAMD9L by PCR of an aggressive fibromatosis tumor cDNA library. The deduced protein contains an N-terminal SAM domain. Database analysis indicated that SAMD9L can undergo alternative splicing leading to an alternative coding region. PCR analysis detected SAMD9L in all adult and fetal human tissues examined except some tumor tissues. Orthologs of SAMD9L were detected in all mammals examined but not in chicken, frog, or fish species. They noted that while Samd9 is absent from the mouse genome due to a mouse-specific gene rearrangement, Samd9l is found in the mouse.