Stonin 2 (STON2)

Endocytosis of cell surface proteins requires a dynamic complex of proteins that assemble on the inner surface of the plasma membrane. Stonin-2 is a component of the endocytic machinery that likely regulates vesicle endocytosis.

The deduced 702-amino acid protein has a calculated molecular mass of about 79 kD. STN2 contains an N-terminal proline-rich domain, followed by a stonin homology domain and a C-terminal domain homologous to the signal-binding domain of adaptor protein (AP) complex mu subunits. STN2 was recovered in equal amounts in the cytosolic and membrane fractions of HeLa cell lysates. Membrane-associated STN2 could be partially extracted under high salt or basic conditions, indicating that it is likely a peripheral membrane protein