Striatin (STRN)

Striatin, a quantitatively minor protein belonging to the WD-repeat family of proteins, is a Ca²⁺/calmodulin-binding protein mostly expressed in the striatum and in the motor and olfactory systems.

Generally associated with membranes, striatin is mostly found in dendritic spines where it is likely to play a role in Ca²⁺-signaling events. The predicted corresponding peptide is potentially able to form a basic amphiphilic helix, as is often the case for many known calmodulin-binding sites. Calmodulin binding to striatin is Ca²⁺-dependent, with half-maximal binding occurring around 0.5 μm free Ca²⁺. In the presence of Ca²⁺, the equilibrium dissociation constant of calmodulin/striatin fusion protein complex is 40 ± 5 nm.