Stromal Membrane Associated Protein 2 (SMAP2)
SMAP1L; Stromal Membrane-Associated GTPase-Activating Protein 2; Small ArfGAP2; Stromal membrane-associated protein 1-like
SMAP2 exhibits GAP activity and interacts with clathrin heavy chain (CHC). SMAP2 interacts with the clathrin assembly protein CALM. Unlike SMAP1, however, SMAP2 appears to be a regulator of Arf1 in vivo, because cells transfected with a GAP-negative SMAP2 mutant were resistant to brefeldin A. SMAP2 colocalized with the adaptor proteins for clathrin AP-1 and EpsinR on the early endosomes/trans-Golgi-network (TGN). Moreover, overexpression of SMAP2 delayed the accumulation of TGN38/46 molecule on the TGN. This suggests that SMAP2 functions in the retrograde, early endosome-to-TGN pathway in a clathrin- and AP-1-dependent manner. Thus, the SMAP gene family constitutes an important ArfGAP subfamily, with each SMAP member exerting both common and distinct functions in vesicle trafficking.
Organism species: Homo sapiens (Human)
- Customized Service n/a Recombinant Stromal Membrane Associated Protein 2 (SMAP2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Stromal Membrane Associated Protein 2 (SMAP2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Stromal Membrane Associated Protein 2 (SMAP2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Stromal Membrane Associated Protein 2 (SMAP2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Stromal Membrane Associated Protein 2 (SMAP2) ELISA Kit Customized Service Offer
Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Stromal Membrane Associated Protein 2 (SMAP2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Stromal Membrane Associated Protein 2 (SMAP2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Stromal Membrane Associated Protein 2 (SMAP2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Stromal Membrane Associated Protein 2 (SMAP2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Stromal Membrane Associated Protein 2 (SMAP2) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Stromal Membrane Associated Protein 2 (SMAP2) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Stromal Membrane Associated Protein 2 (SMAP2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Stromal Membrane Associated Protein 2 (SMAP2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Stromal Membrane Associated Protein 2 (SMAP2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Stromal Membrane Associated Protein 2 (SMAP2) ELISA Kit Customized Service Offer