Structural Maintenance Of Chromosomes Protein 1B (SMC1B)

SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis. The deduced 1,248-amino acid protein has an N-terminal Walker A box, a central ABC ATPase signature motif, and a C-terminal Walker B box. It also has an extended coiled-coil domain with heptad repeats and a hinge region. Smc1l2 shares highest similarity with Smc1. Northern blot analysis of several mouse tissues detected a 4.5-kb Smc1l2 transcript only in testis. In rat spermatocytes, Smc1l2 localized along the axial elements (AEs) of synaptonemal complexes in prophase I. Most Smc1l2 dissociated from the chromosome arms in late-pachytene-diplotene cells. Smc1l2 remained associated with chromatin at the centromeres up to metaphase II.