Succinate Coenzyme A Ligase, ADP Forming, Beta Subunit (SUCLA2)

SUCLA2 encodes the beta-subunit of the ADP-forming succinyl-CoA synthetase (SCS-A; EC 6.2.1.5). SCS is a mitochondrial matrix enzyme that catalyzes the reversible synthesis of succinyl-CoA from succinate and CoA. The reverse reaction occurs in the Krebs cycle, while the forward reaction may produce succinyl-CoA for activation of ketone bodies and heme synthesis. GTP-specific (SCS-G; EC 6.2.1.4) and ATP-specific (SCS-A) isoforms of SCS catalyze GTP-dependent and ATP-dependent reactions, respectively. SCS is composed of an invariant alpha subunit and a beta subunit that determines the enzyme's nucleotide specificity.The predicted 411-amino acid human A-beta protein shares 89 to 95% identity with that of pigeon, mouse, and pig, and 38 to 48% identity with the beta subunit of bacterial SCSs.