Succinate Coenzyme A Ligase, GDP Forming, Beta Subunit (SUCLG2)

SUCLG2 encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12.

The predicted 395-amino acid human G-beta protein shares 89 to 94% identity with that of pigeon, mouse, and pig, and 38 to 48% identity with the beta subunit of bacterial SCSs. Human A-beta and G-beta are 53% identical. RT-PCR revealed that G-beta is widely expressed. Although the level of G-beta mRNA appears to be lower than that of A-beta in most human and mouse tissues, G-SCS was generally the predominant enzyme activity in rat and mouse tissues.