Sulfotransferase Family 1C, Member 4 (SULT1C4)

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.

SULT1C4 encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds.The deduced 302-amino acid protein has a calculated molecular mass of 35.5 kD. SULT1C2 shares 62.9% amino acid identity with SULT1C1. RNA dot blot analysis detected high expression of SULT1C2 only in fetal lung and kidney, with lower levels in fetal heart and in adult kidney, ovary, and spinal cord.