Sulfotransferase Family 1C, Member 2 (SULT1C2)

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.Exon 1 is untranslated. A SULT1C1 splice variant utilizes cryptic splice sites within an Alu repetitive element within intron 3; the additional exon was designated exon 3b. The 5-prime flanking region of the SULT1C1 gene contains no TATA or CAAT motifs.