Suppressor Of Ty 3 Homolog (SUPT3H)

Ogryzko et al. (1998) identified a human polypeptide, which they called SPT3, as a subunit of the P/CAF complex. The predicted 317-amino acid protein shows 51% amino acid sequence similarity with yeast SPT3. Struhl and Moqtaderi (1998) reviewed the potential roles of the PCAF complex in transcription.

By searching for genes within a region of chromosome 6 associated with cleidocranial dysplasia, followed by database analysis and screening of a human craniofacial cDNA library, Yu et al. (1998) cloned the SUPT3H gene. The deduced protein contains 399 amino acids.By genomic sequence analysis, Yu et al. (1998) mapped the SUPT3H gene to chromosome 6p21.3-p21.1.