Sushi Repeat Containing Protein, X-Linked 2 (SRPX2)

SRPX2 encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and mental retardation.The deduced 465-amino acid protein has a calculated molecular mass of 53 kD. It has an N-terminal signal peptide and 3 consensus sushi repeats, each of which spans approximately 60 amino acids and contains 6 conserved cysteines. SRPUL shares 47% amino acid identity with SRPX . Northern blot analysis detected highest expression of a 2.5-kb SRPUL transcript in heart, ovary, and placenta, with little to no expression in other tissues examined.