Synaptic Vesicle Glycoprotein 2B (SV2B)

The SV2B protein was recognized by the anti-SV2 antibody. Expression of SV2B was limited to neural tissue. While both forms of SV2 were expressed in all brain regions, SV2B was expressed at highest levels in the cortex and hippocampus, whereas the highest level of expression of SV2A was in subcortical regions.

The deduced protein contains 683 amino acids and shares 94.9% identity with rat Sv2b. RT-PCR ELISA detected highest expression of SV2B in brain, and low levels in heart, pancreas, and testis, but not in other tissues examined.This variant encodes the same Sv2b protein but has an elongated 3-prime untranslated region that is AU-rich and contains several AUUUA elements.