Synaptic Vesicle Glycoprotein 2C (SV2C)

The SV2C protein shares 62% identity with SV2A and 57% identity with SV2B, and contains 12 transmembrane regions and a protein kinase C phosphorylation site between transmembrane domains 6 and 7 in common with these proteins. Two negatively charged amino acids in the first transmembrane domain constitute another conserved motif, indicating that SV2C could transport positively charged substrates like chloride or ATP.

High levels of SV2C were found primarily in phylogenetically old brain regions such as the pallidum, the substantia nigra, the midbrain, the brainstem, and the olfactory bulb. SV2C was undetectable in the cerebral cortex and the hippocampus, and found at low levels in the cerebellar cortex.