Synaptogyrin 3 (SYNGR3)

SYNGR3 encodes an integral membrane protein. The gene belongs to the synaptogyrin gene family. Like other members of the family the protein contains four transmembrane regions. The exact function of this protein is unclear.

By searching an EST database for sequences related to rat and human SYNGR1, Kedra et al. (1998) identified cDNAs encoding SYNGR2 and SYNGR3. Like other members of the synaptogyrin family, the predicted 206-amino acid SYNGR3 protein contains 4 transmembrane regions. Northern blot analysis revealed that the 2.2-kb SYNGR3 mRNA is expressed in brain and placenta only.By fluorescence in situ hybridization, Kedra et al. (1998) mapped the SYNGR3 gene to chromosome 16pter.