Synaptojanin 2 Binding Protein (SYNJ2BP)

The 3-prime region of the transcript is AU rich and contains multiple mRNA instability repeats. The deduced 206-amino acid protein contains an N-terminal amphipathic helix, followed by a PDZ domain and a C-terminal transmembrane domain. Omp25 mRNA was widely expressed in rat tissues. Omp25 localized to the mitochondrial outer membrane via its C-terminal transmembrane region, with the PDZ domain facing the cytoplasm.

Overexpression of Omp25 resulted in perinuclear clustering of mitochondria in transfected cells, and this effect was mimicked by enforced expression of Synj2a on the mitochondrial outer membrane but not by a Synj2a mutant lacking the inositol-5 phosphatase domain.