Synaptotagmin Like Protein 5 (SYTL5)

SYTL5 belongs to the synaptotagmin-like (Slp) protein family, which contains a unique homology domain at the N-terminus, referred to as the Slp homology domain (SHD). The SHD functions as a binding site for Rab27A, which plays a role in protein transport. Expression of this gene is restricted to placenta and liver, suggesting that it might be involved in Rab27A-dependent membrane trafficking in specific tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. SYTL5 was selected for investigation of protein expression in breast tumours. Exact correlations between predicted and actual molecular weights are not unexpected. SYTL5 protein and mRNA expression correlate strongly, both being expressed at high levels in MCF-7 cells but absent or at very low levels in Hs-578T cells.