Synaptotagmin VI (SYT6)

Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis.

Li et al. (1995) cloned rat Syt6. RT-PCR detected expression of Syt6 in all tissues examined. By in vitro assay of recombinant protein, Li et al. (1995) showed that Syt6 bound adaptor protein-2 in a Ca(2+)-independent manner. However, unlike several other synaptotagmins, Syt6 did not bind phospholipids, and binding to syntaxin was Ca(2+)-independent.