Synaptotagmin X (SYT10)

Synaptotagmins constitute a family of membrane-trafficking proteins that are characterized by an N-terminal transmembrane region (TMR), a variable linker, and two C-terminal C2 domains - C2A and C2B. There are 15 members in the mammalian synaptotagmin family. There are several C2-domain containing protein families that are related to synaptotagmins, including transmembrane (Ferlins, E-Syts, and MCTPs) and soluble (RIMs, Munc13s, synaptotagmin-related proteins and B/K) proteins. In particular Syt-10, a gene that is barely detectable in the native brain, shows a strong up-regulation in the acute phase after status epilepticus.the syt X gene contains additional highly conserved amino acid sequences found in syt VI and another synaptotagmin gene, p65C, isolated from the marine ray.