Synovial Sarcoma Translocation Gene On Chromosome 18 (SS18)

The SYT protein appears to act as a transcriptional coactivator and the SSX proteins as corepressors.SYT also has a C-terminal domain, designated the QPGY domain because it is rich in glutamine, proline, glycine, and tyrosine, that contains the transcriptional activator sequences.

It was found to have been conserved during evolution and to be part of a region of synteny between human and mouse chromosomes 18. In early embryogenesis, mouse Syt is ubiquitously expressed. In later stages, the expression becomes confined to cartilage tissues, specific neuronal cells, and some epithelium-derived tissues. In mature testis, expression was specifically observed in primary spermatocytes.