Synovial Sarcoma Translocation Gene On Chromosome 18 Like Protein 1 (SS18L1)

N-terminal deletions of CREST led to an increase in transactivation in unstimulated neurons but did not affect the level of transactivation seen after stimulation. In contrast, C-terminal deletions did not affect transactivation in unstimulated cells but markedly attenuated calcium-induced transactivation. A deletion of the last 9 amino acids led to a 50% decrease in depolarization-induced transactivation, whereas a deletion that removed the last 135 amino acids completely abolished inducible transactivation. Therefore, both the N- and C-terminal domains contribute to CREST-mediated transcription; the N-terminal domain is required for suppressing transactivation in the basal state, and the C-terminal domain is required for calcium-induced transactivation.