Synovial Sarcoma, X Breakpoint 3 (SSX3)

CT5.3; Cancer/testis antigen 5.3

Synovial Sarcoma, X Breakpoint 3 (SSX3)
By screening a testis cDNA library with a partial fragment of the SSX2 gene, de Leeuw et al. (1996) identified SSX3, a novel member of the Kruppel-associated box (KRAB)-containing SSX gene family. SSX3 encodes a deduced 188-amino acid protein that shares 90% sequence identity with SSX2.
The proximal Xp segment contains several low-copy repeats, suggesting that several duplication events occurred in this region.Unlike SSX1 and SSX2, SSX3 appears not to be involved in the chromosome translocation t(X;18)(p11.2;q11.2) commonly found in synovial sarcomas. Gure et al. (1997) independently cloned the SSX3 gene and showed that it is expressed in normal testis only. Analysis of 12 melanoma cell lines detected no expression of SSX3.

Organism species: Homo sapiens (Human)