Syntaxin 8 (STX8)

The predicted 236-amino acid human protein shares 23% identity with syntaxin-6. Like other syntaxins, syntaxin-8 is anchored to membranes by a C-terminal hydrophobic domain and appears to contain a helical domain involved in the formation of a SNARE complex.

Syntaxin-8 was expressed as a 1.3-kb mRNA in all human tissues tested, with the highest levels in heart. When expressed in mammalian cells, syntaxin-8 colocalized with markers of the endoplasmic reticulum (ER).Syntaxin-8 functions as a vesicle trafficking protein in the early secretory pathway, possibly mediating retrograde transport from cis-Golgi membranes to the ER. syntaxin-8 as a protein that interacted with the regulatory (R) domain of the CFTR protein in a yeast 2-hybrid screen.