T-Box Protein 10 (TBX10)

The TBX10 gene encodes a protein containing a T box with high sequence similarity to the T box of TBX1; the authors concluded that TBX10 is a member of the TBX1 subfamily. TBX10 and TBX1 also share regions of high sequence identity C-terminal to their T boxes. RT-PCR analysis suggested that TBX10 is expressed in human brain, ovary, uterus, pituitary, and fetal kidney. Northern blot analysis showed mouse Tbx10 expression in adult brain, liver, and kidney, and at embryonic days 10.5 to 15.5. RT-PCR analysis detected mouse Tbx10 expression in adult ovary, uterus, and kidney, but not in testis. In situ hybridization analysis suggested that the expression pattern of Tbx10 overlaps that of Tbx1 at 12.5 days' gestation, particularly in lung mesenchyme and the tissues of the developing ear.