T-Cell Leukemia Homeobox Protein 2 (TLX2)

The mouse Hox11l1 gene is expressed from embryonic day 9.5 through day 13.5 and is specifically detectable in the dorsal root ganglia, cranial and enteric nerve ganglia, and adrenal glands, while in adult animals its expression is limited to the adrenal gland and the intestine. Since the expression of Hox11l1 is restricted to tissues derived from neural crest cells, Hatano et al. (1997) hypothesized a role for this gene in the proliferation and/or differentiation of enteric peripheral nervous system.Iitsuka et al. (1999) identified a retinoic acid response element in the human and mouse HOX11L1 promoters. They also identified an enhancer element in the mouse promoter that was crucial for tissue-specific expression, and this element was conserved in the human promoter.