TBC1 Domain Family, Member 24 (TBC1D24)

TBC1D24 encodes a 553-amino acid protein. RT-PCR analysis showed TBC1D24 expression in multiple human tissues, with highest expression in brain, followed by testis, skeletal muscle, heart, kidney, lung, and liver. Tbc1d24 was expressed in the cortex and hippocampus of developing mouse brain, with increased expression during cortical development, particularly in the internal part of the cortical plate and in the subventricular zone. The deduced 595-amino acid protein contains a TBC domain, suggesting it is involved in cell signaling. RT-PCR ELISA detected low expression of TBC1D24 in all adult and fetal tissues examined except spleen, which showed no expression. Expression was moderate in amygdala and cerebellum and low in all other adult brain regions examined.