TBC1 Domain Family, Member 1 (TBC1D1)

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. The deduced 763-amino acid protein contains a TBC1 domain. RT-PCR ELISA detected highest TBC1D1 expression in kidney, testis, ovary, and corpus callosum. Expression was intermediate in all other adult and fetal tissues and specific adult brain regions examined.of Tbc1d1 in mouse skeletal muscle cells increased fatty acid uptake and oxidation, whereas overexpression of Tbc1d1 had the opposite effect. Recombinant congenic mice lacking Tbc1d1 showed reduced body weight, decreased respiratory quotient, increased fatty acid oxidation, and reduced glucose uptake in isolated skeletal muscle.