TCDD Inducible Poly ADP Ribose Polymerase (TIPARP)

TIPARP, encodes a deduced 657-amino acid protein that shares 91.8% and 52.7% sequence identity with mouse and fugu Tiparp proteins, respectively. The proteins in all 3 species contain 3 highly conserved domains: a WWE (trp, trp, glu) domain, a PARP (poly(ADP-ribose) polymerase)-like catalytic domain, and a novel TPH (TIPARP homologous) domain.

The N-terminal part of the TPH domain contains a CCCH-type zinc finger. Katoh and Katoh (2003) noted that the deduced proteins of 2 human genes, which they called FLJ226093 (PARP12) and ZAP (ZC3HAV1), contain the same 3 conserved domains and share 27.5% and 26% overall sequence identity with TIPARP, respectively.