TDP Glucose-4,6-Dehydratase (TGDS)

TGDS belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily. In enzymology, a dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) is an enzyme that catalyzes the chemical reaction: dTDP-glucose<=>dTDP-4-dehydro-6-deoxy-D-glucose + H₂O

This enzyme has one substrate, dTDP-glucose, and two products, dTDP-4-dehydro-6-deoxy-D-glucose and H₂O.This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. This enzyme participates in 4 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, polyketide sugar unit biosynthesis, and biosynthesis of vancomycin group antibiotics. It employs one cofactor, NAD+.