TEA Domain Family, Member 3 (TEAD3)

TEAD3is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon.

TEF5 binds to multiple functional sites in the CSH2 enhancer. Mutations in these sites that disrupted TEF5 binding also inactivated the transcription-enhancing activity of the element. The authors showed that the placental protein f/chorionic somatomammotropin enhancer factor-1 (PPf/CSEF1), which binds to TEF-binding sites in the CSH2 enhancer, is a proteolytic degradation product of TEFs.