TGFB Induced Factor 2 (TGIF2)

Homeodomain transcription factors play fundamental roles in directing cellular proliferation and differentiation and in determining cell fates. TGIF2 is a member of a subfamily of transcription factors with an atypical homeodomain called a TALE (3-amino acid loop extension) that inserts 3 amino acids between helices 1 and 2 of the homeodomain.

The deduced 237-amino acid protein has a calculated molecular mass of about 30 kD and contains a TALE sequence. It also has a repression domain containing a proline-rich region that is a putative SH3 domain-binding site and is thought to be involved in transcriptional regulation. The homeodomain of TGIF2 is 77% identical to the corresponding domain within TGIF, but outside this domain the similarity is only 49%.