TGFB Induced Factor Homeobox 2 Like Protein, X-Linked (TGIF2LX)

TGIF2LX encodes a member of the TALE/TGIF homeobox family of transcription factors. Testis-specific expression suggests that this gene may play a role in spermatogenesis. A homolog of this gene lies within the male specific region of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Y transposition.

A single basepair deletion in the human TGIFLY (as compared with TGIFLX) created a different reading frame, where the C-terminal residues shared by TGIFLX and other TGIF proteins were missing. The conservation, similarity to protein-encoding transcription factors, and specific expression in testis pointed to a transcriptional role for TGIFLX/Y in this tissue.TGIFLX/Y gene has a 2,666-bp mRNA encoded by 2 exons separated by a 96-bp intron.