THUMP Domain Containing Protein 1 (THUMPD1)

THUMPD1 contains a THUMP domain which is a module of 100-110 amino acid residues which is involved RNA metabolism. The function of this protein has not yet been determined.

The THUMP domain is shared by 4-thiouridine, pseudouridine synthases and RNA methylases and is probably an RNA-binding domain that adopts an alpha/beta fold similar to that found in the C-terminal domain of translation initiation factor 3 and ribosomal protein S8. The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.The existence of a new putative RNA-binding domain, abbreviated THUMP, was deduced from sequence comparison of various proteins known or predicted to be involved in RNA metabolism. For a long time, the THUMP domain remained essentially uncharacterized.