TRAF Type Zinc Finger Domain Containing Protein 1 (TRAFD1)

The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses.The deduced human and mouse proteins contain 582 and 576 amino acids, respectively. TRAFD1 has an N-terminal RING finger domain, followed by a zinc finger domain, and TRAF-N and TRAF-C domains. Northern blot analysis of mouse tissues showed expression skeletal muscle, brain, kidney, spleen, and bone marrow.FLN29 is activated by STAT1 and functions as a negative feedback regulator of TLR signaling downstream of TRAF6.Small interfering RNA-induced downregulation of Fln29 reversed these effects and increased the production of nitrous oxide. Fln29 inhibited Toll-like receptor (TLR) signaling by interacting directly with Traf6.