TRK Fused Gene (TFG)

Mencinger et al. (1997) identified the complete TFG gene by searching for ESTs that were similar to the N-terminal regions of EWS and FUS. TFG encodes a predicted 400-amino acid protein with a putative N-terminal coiled-coil region. On Northern blots, the 2.2-kb TFG mRNA was expressed in all tissues tested. Greco et al. (1995) stated that a coiled-coil structure and ubiquitous expression are features shared by all NTRK1-activating genes as well as genes that activate other tyrosine kinase protooncogenes.

Greco et al. (1995) localized the TFG gene to chromosome 3 by PCR of a hybrid panel. Mencinger et al. (1997) mapped the TFG gene to 3q11-q12 by fluorescence in situ hybridization.