TSC22 Domain Family, Member 4 (TSC22D4)

TSC22D4 is a member of the TSC22 domain family of leucine zipper transcriptional regulators. RT-PCR assays detected Tsc22d4 expression during mouse embryonic development with expression first detected at stage 98.5 followed by a sharp increase during the next 24 hours that coincided with initiation of Lhx3 expression and preceded formation of the pituitary rudiment. A second increase in Tsc22d4 expression at embryonic day 12.5 coincided with development of Rathke's pouch. Tsc22d4 expression was also detected in the entire central nervous system.The deduced 395-amino acid human protein contains a TSC box and leucine zipper region and has a calculated molecular mass of 41 kD. TSC22D4 shares similarity with TSC22D1, TSC22D3, KIAA0669, and Drosophila 'shortsighted' shs over the TSC box leucine zipper domain.